Sep 6, 2019
Dr. Pastore and Lexie cover how certain variations of specific genes can affect your performance, your nutrition, your cravings and even how food tastes.
In-depth topics include how genetics affect:
Genetic SNPs covered in the episode:
KCTD10-GG
MMAB-GG
MVK
May cause low HDL (“good”) cholesterol levels with high carbohydrate consumption (~231g+ per day)
SLC2A2 rs5400 - T allele (even just one)
“Sweet tooth” gene, linked to over-eating, not feeling satisfied after sugar consumption, less sensitive to feeling the affects of high glucose levels in blood
TAS1R3-AA
TAS1R3-GA
Sugar tastes less sweet, increases the likelihood over overconsumption of sugar and artificial sweeteners
TAS2R38-C allele
TAS2R38-G allele
Do not like the taste of bitter foods (coffee, broccoli, kale, Brussels sprouts), over-salt or sweeten foods to cover up the taste
TAS2R38-TT
Find bitter foods less bitter than other people (enjoy broccoli, cabbage, kale, etc)
COL5A1-TT
Decreased elasticity and range of motion in joints. Increased risk of injuring joints, connective tissue (tendons/ligaments) and soft tissue.
COL5A1-CC
Protective genotype, reduced rate of tendon injury
COL1A1-TT
Decreased risk of injuring joints, connective tissue (tendons/ligaments) and soft tissue.
GDF5-T allele
Increased risk for joint injuries, can be a warning sign of early (mid-40’s) onset osteoarthritis
MC4R-C allele
KCDT15-C allele
Increases likelihood of higher BMI (from fat mass), slows the process of weight loss, can cause more cravings for higher caloric/processed food intake
COMT-GG
Increases the likelihood to overeat
SHTB2, LEP, PCSK1-2, and FTO are currently being researched for their connection to obesity.