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The Pastore Podcast

Sep 6, 2019

Dr. Pastore and Lexie cover how certain variations of specific genes can affect your performance, your nutrition, your cravings and even how food tastes.


In-depth topics include how genetics affect:

  • High carbohydrate consumption and low HDL cholesterol levels
  • How food tastes, and why some people can never get enough sugar
  • How your risk for tendon/ligament/joint injury is increased/decreased
  • Over-eating and difficulty losing weight




Genetic SNPs covered in the episode:





May cause low HDL (“good”) cholesterol levels with high carbohydrate consumption (~231g+ per day)


SLC2A2 rs5400 - T allele (even just one)

“Sweet tooth” gene, linked to over-eating, not feeling satisfied after sugar consumption, less sensitive to feeling the affects of high glucose levels in blood




Sugar tastes less sweet, increases the likelihood over overconsumption of sugar and artificial sweeteners


TAS2R38-C allele

TAS2R38-G allele

Do not like the taste of bitter foods (coffee, broccoli, kale, Brussels sprouts), over-salt or sweeten foods to cover up the taste



Find bitter foods less bitter than other people (enjoy broccoli, cabbage, kale, etc)



Decreased elasticity and range of motion in joints. Increased risk of injuring joints, connective tissue (tendons/ligaments) and soft tissue.



Protective genotype, reduced rate of tendon injury



Decreased risk of injuring joints, connective tissue (tendons/ligaments) and soft tissue.


GDF5-T allele

Increased risk for joint injuries, can be a warning sign of early (mid-40’s) onset osteoarthritis


MC4R-C allele

KCDT15-C allele

Increases likelihood of higher BMI (from fat mass), slows the process of weight loss, can cause more cravings for higher caloric/processed food intake



Increases the likelihood to overeat


SHTB2, LEP, PCSK1-2, and FTO are currently being researched for their connection to obesity.